Location: NCI Shady Grove, 9609 Medical Center Dr, Rockville, MD 20850
All times listed are in Eastern Time (ET)
Day- 1: Thursday, September 12th, 2024
8:00 – 9:00 AM
9:00 – 9:15 AM
9:15 – 9:20 AM
9:20 – 10:20 AM
Check-In/ Pick-up Meeting agenda/ name-tag etc.
NCI Opening Remarks - Dr. Dan Gallahan, Director, DCB, NCI
Introduction of Keynote speaker and moderator for Q&A (Dr. Dan Gallahan)
Keynote Talk: The Multifactorial Nature of Multidrug Resistance in Cancer
Dr. Michael Gottesman, Deputy Director for Intramural Research, Center for Cancer Research, NCI
10:20 – 10:35 AM
10:35 – 11:20 AM
Break
Thematic Panel Discussion- 1
Topic: Race/Ethnicity/Gender-based disparities in clinical patterns or biological mechanisms of acquired resistance
Panelists: Drs. Victoria Seewaldt (City of Hope), Jose Trevino (VCU), Jeffrey Tyner (OHSU U54) Pankaj Singh (PSRC U54) and Tiffany Wallace (NCI)
Moderator: Dr. Tiffany Wallace (NCI)
11:20- 11:40 AM
11:40 AM- 12:25 PM
ARTNet CDMC Presentation- Dr. Alan Hutson
Collaborative Pilot Project Update Talks -1 (15 min each: 12 min talk & 3 min Q&A)
Moderator: Dr. Jeffrey Hildesheim (NCI)
11:40 – 11:55
Metabolic targeting of platinum resistance in humanized models of head and neck cancer
Presenter: Dr. Vlad Sandulache, H-CARR U54
Collaborators: Drs. Boyi Gan, ARTI U54 & Trever Bivona, BAATAAR-UP U54
11:55 – 12:10
Characterizing metabolomic changes during acquired radioresistance in pancreatic cancer
Presenter: Dr. Boyi Gan, ARTI- U54
Collaborators: Dr. Pankaj Singh, PCAC U54
12:10 – 12:25
Improving AI/ML readiness of ARTNET data to serve as a catalyst for trans- network modeling
Presenter: Dr. Shannon McWeeney, OHSU AML U54
Collaborator: Drs. Alan Hutson, Song Liu, CDMC U24
12:25 – 1:30 PM
Lunch Break (On your own)
1:30 – 2:15 PM
Collaborative Pilot Project Update Talks- 2 (15 min each: 12 min talk, 3 min Q&A)
Moderator: Dr. Michael Espey (NCI)
1:30 – 1:45
Transcriptional and epigenetic states in PD-1 resistance in a model of AML
Presenter: Dr. Evan Lind, OHSU AML U54
Collaborator: Dr. Mark Long, CDMC U24
1:45 – 2:00
Modulating transcription factor mobility and positioning with bivalent chromatin targeting chimeras
Presenter: Colton Sanders, Collaborator PI: Dr. Jonathan Ostrem
Collaborator: Dr. Trever Bivona, BAATAAR-UP U54
2:00 – 2:15
Imaging Metabolic Alterations Related to Treatment in Lung Cancer
** Virtual Presenter: Dr. Stephen Lai, H-CARR U54
Collaborator: Dr. Jack Roth, BAATAAR-UP U54
2:15 – 3:45 PM
Working Group Presentations and discussions and voting on co-chair nominations
2:15 – 3:00
Functional Screens and Assay Development WG
Drs. Erik Knudsen (Roswell Park) and Alice Soragni (UCLA)
3:00 – 3:15
Discussion on Workshop/ White Paper/ cross- network & other activities
3:15 – 3:30
Cell States, Metabolism and Inflammatory Microenvironment
Drs. Chunru Lin (MD Anderson) and Michael Deininger (Versiti)
3:30 – 3:45
Discussion on Workshop/ White Paper/ Cross- network & other activities
3:45- 4:00 PM
BREAK
4:00 - 4:45 PM
Thematic Panel Discussion- 2
Topic: Computational Methodologies and Challenges in Utilizing AI/ML for Acquired Resistance Research
Panelists: Drs. Ryan Weil (FNLCR), Shannon McWeeney (OHSU), Tao Liu (CDMC) and Erika Kim (NCI)
Moderator: Dr. Sarah Mullin (CDMC)
4:45 - 5:00 PM
Closing Remarks and Adjourn Day -1
Day- 2: Friday, September 13th, 2024
7:30 – 8:30 AM
8:15 – 8:20 AM
8:20 – 10:35 AM
Check-In/ Pick-up Meeting agenda/ name-tag etc.
Opening Remarks (DCTD/DCB)- Dr. Michael Espey, NCI
U54 Center Presentations (25 mins- 20 mins talk + 5 mins Q&A)
Moderators: Drs. Tapan Bera and Mihoko Kai (NCI)
8:20 – 8:45 AM
Architecture and Trajectory of Acquired Resistance to Therapy in AML U54 Progress Update
Dr. Jeffrey Tyner, Oregon Health and Science University
8:45 – 9:10 AM
Bay Area & Anderson Team Against Acquired Resistance (BAATAAR-UP) U54 Progress Update
Drs. Trevor Bivona, Collin Blakely , University of California, San Francisco
9:10 - 9:35 AM
Acquired Resistance to Therapy and Iron (ARTI) U54 Center Progress update
Dr. Boyi Gan, MD Anderson Cancer Center
9:35 - 9:50 AM
Break
9:50 - 10:15 AM
Studying Disparities in Head and Neck Squamous Cancer Outcomes - Separating Borough from Biology in the Bronx
Dr. Thomas Ow, Montefiore Medical Center, H-CARR U54
10:15 - 10:40 AM
Pancreatic Cancer ARTNet Center (PCAC) U54 Progress Update
Dr. Pankaj Singh, University of Oklahoma Health Science Center (OUHSC)
10:40- 12:00 PM
Early Career investigator Talks (15 min each: 12 min talk & 3 min Q&A)
Moderator: Dr. Sudhir Kondapaka (NCI)
10:40 - 10:55 AM
Dysregulation of SPP1 promotes tumor invasion and metastasis in cisplatin resistant HNSCC.
Dr. Abdullah Osman, MD Anderson, H-CARR U54
10:55 - 11:10 AM
Tumor microenvironment-mediated acquired resistance to radiation- induced ferroptosis.
Dr. Dadi Jiang, Assistant Professor, MD Anderson, ARTI U54
11:10 - 11:25 AM
Insights into acquired resistance networks across the tumor-tumor microenvironment ecosystem revealed by spatial profiling.
Whitney Tamaki, Graduate Student, UCSF, BAATAAR-UP U55
11:25 - 11:40 AM
Role of ROS homeostasis in therapeutic resistance of pancreatic cancer.
Dr. Surendra Shukla, Assistant Professor, OUHSC, PCAC U54
12:00- 12:10 PM
Closing Remarks and Meeting Adjourn
