ARTNet Moonshot Members

ARTNet Revision Projects

The Revision Projects (supported under RFA-CA-19-049 R01, RFA-CA-19-050 U01, RFA-CA-19-051 U54, RFA-CA-19-052 P01, RFA-CA-19-053 P50), through administrative supplement, leverage the expertise in the broader NCI-funded grant portfolio (R01 Research Projects, U01 Research Projects, U54 Specialized Centers, P01 Research Program Projects, P50 Specialized Centers) to tackle drug resistance in cancer.

The purpose is to support the addition of new aims and directions to currently funded NCI-funded grant portfolio in underexplored areas of basic and preclinical evaluation of therapeutic resistance. These revision applications are expected to be complementary (but not duplicative) of on-going research activities the original project and ultimately accelerate the translational success of ongoing and future clinical trials.

3U01CA223976-03S1
Glioblastoma Tumor Microenvironmental Influence on Acquired and Inherent Cancer Therapy Resistance

University of Alabama at Birmingham Willey, Christopher Gillespie, Yancey
Hjelmeland, Anita

3P50CA186786-07S1
Targeting LSD1 in Neuroendocrine Prostate Cancer - Michigan Prostate SPORE

University of Michigan at Ann Arbor Alumkal, Joshi Chinnaiyan, Arul

3U01CA231776-03S1
Tumor-barcoding coupled with high-throughput sequencing of a novel chemoradiation resistant SCLC mouse model

University of Maryland Tran, Phuoc T

3R01CA175397-07S1
A vicious cycle of pyroptotic cancer cells and fibroblasts fuels chemoresistance

Houston Methodist Chan, Keith Syson

3R01CA231011-03S1
Long Noncoding RNA Advocates Immune Resistant Microenvironment

MD Anderson Cancer Center Lin, Chunru

5R01CA254354-02
Targeting the Metabolic Regulator SIRT5 in Acute Myeloid Leukemia

Versiti Deininger, Michael

5R01CA247362-03
RB tumor suppressor as a therapeutic target in ER-positive breast cancer

Roswell Park Comprehensive Cancer Center Knudsen, Eric Witkiewicz, Agnieszka

5R01CA248310-02
Development of a first-in-class mEGFR dimerization inhibitor

University of Michigan at Ann Arbor Nyati, Mukesh

5R01CA244729-02
The Evolution of Sarcoma Drug Sensitivity through Time and Space

University of California, Los Angeles Soragni, Alice Boutros, Paul

5R01CA251872-02
Drivers of metabolic plasticity promote radiation resistance in glioblastoma multiforme

University of California, Los Angeles Vlashi, Erina

5R01CA175495-09
The B7x pathways in the tumor microenvironment

Albert Einsten College of Medicine Zang, Xingxing